A DGK isoform, which resides in the nucleus of PC12 cells, is DGK-theta. Here, we show that nerve growth factor (NGF) treatment of serum-starved PC12 cells results in the stimulation of both a cytoplasmic and a nuclear DGK activity. However, time course analysis shows that cytoplasmic DGK activity peaked earlier than its nuclear counterpart.
Juli 2017. Im Rahmen der Mitgliederversammlung wurde ein neuer Nukleus für unsere Sektion gewählt. David Duncker von der Medizinischen Hochschule Hannover übernimmt für die kommenden zwei Jahre die Position des Sprechers der Sektion. Zur stellvertretenden Sprecherin wurde Victoria Johnson von der Universitätsklinik Gießen gewählt.
(1998) concluded that the nuclear localization of DGK-iota is regulated by phosphorylation in much the same manner as that of DGK … 2020-10-10 Previous evidence has shown that the nucleus contains several DGK isoforms. In this study, we have analyzed the expression and subnuclear localization of DGK‐ζ employing C2C12 mouse myoblasts. Immunocytochemistry coupled to confocal laser scanning microscopy showed that both endogenous and green fluorescent protein‐tagged overexpressed DGK‐ζ localized mostly to the nucleus. Nukleus der Arbeitsgruppe Magnetresonanzverfahren in der Kardiologie der DGK Ingo Eitel, Holger Thiele, Jeanette Schulz-Menger für die AG21.
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DGK-ζ is the only one that contains a nuclear localization sig- nal (NLS).2,3 Diplom “Sachkunde der Herzschrittmacher Therapie” der deutschen Gesellschaft für Kardiologie DGK, Nukleus Rhythmologie. Diplom “Praxis der ICD-Therapie” 25 Feb 2005 nucleus, suggesting different roles for these isozymes. In the devel- oping lung, the expression for DGK and - was transiently elevated.
via dissocierbara neuronala aktivitetsmönster i Nucleus Accumbens som första författare och DGK och JS bidrog lika som äldre författare.
PMID: 16758180 [Indexed for MEDLINE] Publication Types: Furthermore, we report that DGK-zeta associated with nuclear matrix, the fundamental organizing principle of the nucleus where many cell functions take place, including DNA replication, gene expression, and protein phosphorylation. Nuclear DGK-zeta increased during myogenic differentiation of C2C12 cells, while DGK-zeta down-regulation by siRNA markedly impaired differentiation.
E-Mail: granzow@dgk.org Fax: +49 (0) 211 600 692-69 Roland Groß Tel.: +49 (0) 211 600 692-6 5 E-Ma: li gross@dgko. rg www.akademie.dgk.org Teilnahmegebühr: Tenli ahmegebühr :€ 380-, Für Mitglieder der DGK: € 360,-Teilnehmerzahl: max. 30 Registrierung: 1. Ihre Online-Anmeldung 2. Verbindliche Teilnahmebestätigung durch die Akademie 3.
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In biochemical assays, the C terminus of DGK-zeta, which contains a consensus PDZ-binding motif, was found to be necessary and sufficient for association with gamma 1-syntrophin.
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2007-01-01 · The list of subcellular compartments where DGK activity or DGKs have been found includes, but is not limited to, the plasma membrane, the endoplasmic reticulum, the neuromuscular junction, the cytoskeleton, and even the nucleus. In fact, within the nucleus, DGKs appear to be confined to separate, distinct regions (Topham and Prescott, 2002). Indeed, the NES mutant forms of DGK-ζ accumulated in the nucleus to a much greater extent than wild type DGK-ζ. Moreover, treatment with leptomycin B, an inhibitor of leucine-rich type NES, resulted in accumulation of both endogenous and ectopically expressed DGK-ζ in the nucleus, demonstrating that nuclear export of DGK-ζ is chro- We found 15–30% of total cellular DGK-ζ in the nucleus both of COS-7 cells transfected with DGK-ζ complementary DNA and of A172 cells, a glioblastoma-derived line, which express native DGK-ζ .
Further fractionation of the nuclei can be achieved using protocols that have been described ( Ledeen and Wu, 2004 ). ABSTRACT The nucleus contains diacylglycerol ki-nases (DGKs), i.e., the enzymes that, by converting diacylglycerol (DG) into phosphatidic acid, terminate DG-dependent events.
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One DGK, DGK-zeta, contains both a nuclear localization signal and nuclear export signal , suggesting a shuttling between the nucleus and the cytoplasm. Morphological studies on animal tissues report that DGK-zeta predominantly localizes to the nucleus in some cell types, while it exhibits both nuclear and cytoplasmic localization in others.
Verbindliche Teilnahmebestätigung durch die Akademie 3. Überweisung der Kursgebühr auf das Konto: DGK-Akademie Commerzbank Düsseldorf Previous evidence has shown that the nucleus contains several DGK isoforms. In this study, we have analyzed the expression and subnuclear localization of DGK‐ζ employing C2C12 mouse myoblasts.